Cyclodextrin compatible with unique molecular recognition and good biological, not only in chemical separation and analysis, selective catalysis, bio pharmaceuticals, are widely used in the fields of food and environmental protection, but also in the construction of micro to macro structure and orderly, has practical and theoretical significance on the morphology of novel and intelligent super molecular materials and understanding of nature identification of such phenomena. Cyclodextrin supramolecular hydrogel is a new research field in recent years. It is in addition to the basic characteristics of general hydrogels, such as biocompatibility, high moisture content, no drug inactivation characteristics, also has the self assembly and molecular recognition characteristics and the unique intelligence, such as shear, pH value, temperature, light and other stimuli responsive, so the traditional hydrogel research and application will have a significant impact. Through appropriate design regulation of cyclodextrin derivatives and polymers or The guest molecules and polymer structure, and intelligent control can also through supramolecular hydrogels, and inorganic functional hybrid materials further broaden its function and regulation, so as to meet the requirements of application in different fields. However, cyclodextrin supramolecular hydrogels as biomaterials drug / gene delivery vectors and the application of tissue engineering scaffolds, in the actual application process still needs to be balanced in can seek better operability and functionality. In addition, the safe use of cyclodextrin supramolecular hydrogels are also worthy of attention, researchers still need to carry out a wide range of in vitro and in vivo biocompatibility evaluation of biodegradable and related applications. But to be sure, this new type of supramolecular hydrogels have the future development of a wider than conventional hydrogels.