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According to a report from the BBC website on February 6, the University of Hasselt, Belgium, announced that scientists from Belgium and the Netherlands have used the three-dimensional (3D) printing technology to create the first complete titanium-based squat and successfully transplanted it. Giving an 83-year-old woman shows that accurate 3D printing technology can be used to transplant human bones and organs.
Previously, this female patient suffered from osteomyelitis, which damaged the normal function of the jaw. The researchers obtained the exact shape of the jaws of the patient through magnetic resonance imaging (MRI) and used a laser-sintered 3D printer to melt the titanium particles and fuse them together until the model of the patient's lower jaw was remodeled without using any adhesive. Agent. This technology, called "additional production," uses high-precision laser beams to continuously melt very thin titanium metal powder to make organs. Each layer of titanium powder adheres to the cross section of the upper layer. A thickness of 1 mm requires the melting of 33 layers of titanium metal powder, while the manufacture of the entire lower jaw requires the melting of thousands of layers of titanium powder. The resulting chin also has dents and cavities that promote muscle attachment, as well as a sleeve that allows the passage of mandibular nerves to increase the support structure that the patient may need in the future. It is also covered with a biocompatible ceramic layer so that it adheres to the patient's face.
Although about 107 grams of artificial diarrhea is one-third heavier than natural diarrhea, it is not difficult for patients to use it. After the operation was completed, the patient's jaw quickly returned to its original shape, and swallowing, talking, and breathing functions returned to normal. Usually this type of surgery requires two to one month of hospitalization to complete, and the patient completed the mandible transplant in only four hours. Compared to traditional manufacturing methods, 3D printing technology uses less materials and produces shorter production time. Previously the largest 3D-printing transplant was a half-maxilla implant in Finland in 2008. Scientists developed a biocompatible tissue by implanting 3D-printed titanium particles into stem cells and implanting them in the patient's abdomen.
Professor Jules Pokens of Hasselt University stated that this is the first time that a custom organ has been used to replace the entire mandible for the patient. Since 3D printers can fabricate laminates that are only a few microns thick and are compatible with almost all types of raw materials, researchers are exploring ways to fabricate skin graft microchips using 3D printing technology and using the correct deposition of cells to build entire organs. way. Peter Morceres, general manager of Belgian 3D printing company Layerwise, also stated that this is only the beginning. "Additional production" technology will enable LayerWise to produce more complex organs or grafts that meet the needs of patients and will be applied more widely in the future. A range of transplants, not just human bone grafts. (Zhang Hao)
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